Home / Special Issue / JSSH Vol. 29 (S1) 2021 / JSSH(S)-1493-2021

 

Effect of Exercise and Weight Loss in Polycystic Ovarian Syndrome among Obese Women

Thomas Cochrane, Tengku Fadilah Tengku-Kamalden, Rachel Davey and Roxana Dev Omar Dev

Pertanika Journal of Social Science and Humanities, Volume 29, Issue S1, December 2021

DOI: https://doi.org/10.47836/pjssh.29.s1.07

Keywords: Dietary restriction, exercise, fertility, obesity, weight loss

Published on: 14 April 2021

Ovulation and fertility can be improved by weight loss in obese women with Polycystic Ovarian Syndrome (PCOS). The aim of this study was to investigate the effectiveness of a twelve-week supervised exercise program in combination with dietary restrictions for obese women with PCOS. The study is a quasi-experimental research and used an experimental pre- and post-test design. Fifteen women recruited from Fertility Clinic, Jessops Hospital for Women, Sheffield took part in this study. Respiratory exchange ratio (RER), heart rate, perceived exertion (RPE), and Houston non-exercise activity code were recorded. Height, weight, and body girth measurements were taken to calculate body mass index, fat percentage, and lean body weight. The intervention group lost an average of 3.1 kg and gained 3.45 kg of lean body weight. Loss of fat percentage was 12.1%. No significant difference was found in the control group. The RER and heart rate value decreased for the same workload in the intervention group, indicating higher tolerance towards exercise intensity. However, the changes for both groups were not significant. The average group compliance rate was 53% (at least two sessions per week). Bearing in mind the small sample size (n=4) for control, the improvement in fitness, significant weight loss, and body composition change (increase in fat-free mass) was achieved in this study. Twelve weeks of exercise, combined with dietary advice, were sufficient to benefit PCOS obese women. The research has achieved a commendable weight-loss objective and has demonstrated increases in standards of fitness among obese women.

  • Balke, B., & Ware, R. W. (1959). An experimental study of physical fitness of Air Force personnel. United States Armed Forces Medical Journal, 10(6), 675–688.

  • Belfort-DeAguiar, R., & Seo, D. (2018). Food cues and obesity: Overpowering hormones and energy balance regulation. Current Obesity Reports, 7(2), 122–129. doi: 10.1007/s13679-018-0303-1

  • Beltz, N. M., Gibson, A. L., Janot, J. M., Kravitz, L., Mermier, C. M., & Dalleck, L. C. (2016). Graded exercise testing protocols for the determination of VO2max: Historical perspectives, progress, and future considerations. Journal of Sports Medicine, 2016, 1–12. doi: 10.1155/2016/3968393

  • Biswas, M., Thackare, H., Jones, M. K., & Bowen-Simpkins, P. (2002). Lymphocytic hypophysitis and headache in pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology, 109(10), 1184–1186. doi: 10.1111/j.1471-0528.2002.01158.x

  • Brochu, M., Tchernof, A., Dionne, I. J., Sites, C. K., Eltabbakh, G. H., Sims, E. A., & Poehlman, E. T. (2001). What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? The Journal of Clinical Endocrinology & Metabolism, 86(3), 1020–1025. doi: 10.1210/jcem.86.3.7365

  • Bujang, M. A., & Baharum, N. (2017). Guidelines of the minimum sample size requirements for Kappa agreement test. Epidemiology, Biostatistics and Public Health, 14(2), 1–10.

  • Chandler, M. (2018). New thoughts about obesity. Companion Animal, 23(12), 686–695. doi: 10.12968/coan.2018.23.12.686

  • Chaston, T. B., Dixon, J. B., & O’Brien, P. E. (2007). Changes in fat-free mass during significant weight loss: A systematic review. International Journal of Obesity, 31(5), 743–750. doi: 10.1038/sj.ijo.0803483

  • Conway, C. C., Starr, L. R., Espejo, E. P., Brennan, P. A., & Hammen, C. (2016). Stress responsivity and the structure of common mental disorders: Transdiagnostic internalizing and externalizing dimensions are associated with contrasting stress appraisal biases. Journal of Abnormal Psychology, 125(8), 1079–1089. doi: 10.1037/abn0000163

  • de Melo, L. G. P., Nunes, S. O. V., Anderson, G., Vargas, H. O., Barbosa, D. S., Galecki, P., Carvalho, A. F., & Maes, M. (2017). Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 78, 34–50. doi: 10.1016/j.pnpbp.2017.04.027

  • Despres, J. P., Pouliot, M. C., Moorjani, S., Nadeau, A., Tremblay, A., Lupien, P. J., Theriault, G., & Bouchard, C. (1991). Loss of abdominal fat and metabolic response to exercise training in obese women. American Journal of Physiology-Endocrinology and Metabolism, 261(2), 159–167. doi: 10.1152/ajpendo.1991.261.2.e159

  • Dodd, J. M., Turnbull, D. A., McPhee, A. J., Wittert, G., Crowther, C. A., & Robinson, J. S. (2011). Limiting weight gain in overweight and obese women during pregnancy to improve health outcomes: The LIMIT randomised controlled trial. BMC Pregnancy and Childbirth, 11(1), 1–5. doi: 10.1186/1471-2393-11-79

  • Dugdale, A. H. A., Curtis, G. C., Cripps, P., Harris, P. A., & Argo, C. M. (2010). Effect of dietary restriction on body condition, composition and welfare of overweight and obese pony mares. Equine Veterinary Journal, 42(7), 600–610. doi: 10.1111/j.2042-3306.2010.00110.x

  • Gadducci, A. V., de Cleva, R., de Faria Santarém, G. C., Silva, P. R. S., Greve, J. M. D., & Santo, M. A. (2017). Muscle strength and body composition in severe obesity. Clinics, 72(5), 272–275. doi: 10.6061/clinics/2017(05)03

  • Garrow, J. S., & Summerbell, C. D. (1995). Meta-analysis: Effect of exercise, with or without dieting, on the body composition of overweight subjects. European Journal of Clinical Nutrition, 49(1), 1–10.

  • Goodarzi, M. O., Dumesic, D. A., Chazenbalk, G., & Azziz, R. (2011). Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis. Nature Reviews Endocrinology, 7(4), 219–231. doi: 10.1038/nrendo.2010.217

  • Heilbronn, L. K., & Ravussin, E. (2003). Calorie restriction and aging: Review of the literature and implications for studies in humans. The American Journal of Clinical Nutrition, 78(3), 361–369. doi: 10.1093/ajcn/78.3.361

  • Jackson, A., Blair, S. N., Mahar, M. T., Wier, L. T., Ross, R. M., & Stuteville, J. E. (1990). Prediction of functional aerobic capacity without exercise testing. Medicine and Science Sports and Exercise, 22(6), 863. doi: 10.1249/00005768-199012000-00021

  • Kaaks, R., Lukanova, A., & Kurzer, M. S. (2002). Obesity, endogenous hormones, and endometrial cancer risk: A synthetic review. Cancer Epidemiology and Prevention Biomarkers, 11(12), 1531–1543.

  • Kang, J., Chaloupka, E. C., Mastrangelo, M. A., Biren, G. B., & Robertson, R. J. (2001). Physiological comparisons among three maximal treadmill exercise protocols in trained and untrained individuals. European Journal of Applied Physiology, 84(4), 291–295. doi: 10.1007/s004210000366

  • Kannan, S., Srinivasan, D., Raghupathy, P. B., & Bhaskaran, R. S. (2019). Association between duration of obesity and severity of ovarian dysfunction in rat-cafeteria diet approach. The Journal of Nutritional Biochemistry, 71, 132–143. doi: 10.1016/j.jnutbio.2019.05.012

  • Kardani, G., & Rustiawan, H. (2020). Circumference measurements on body contest athletes in Indonesia. [Paper presentation]. 4th International Conference on Sport Science, Health, and Physical Education (ICSSHPE 2019), Bandung, Indonesia. https://doi.org/10.2991/ahsr.k.200214.016

  • MacKenzie-Shalders, K., Kelly, J. T., So, D., Coffey, V. G., & Byrne, N. M. (2020). The effect of exercise interventions on resting metabolic rate: A systematic review and meta-analysis. Journal of Sports Sciences, 38(14), 1–15. doi: 10.1080/02640414.2020.1754716

  • Mascarenhas, L. P. G., Decimo, J. P., Lima, V. A. de, Kraemer, G. de C., Lacerda, K. R. C. de, & Nesi-França, S. (2016). Physical exercise in type 1 diabetes: Recommendations and care. Motriz: Revista de Educação Física, 22(4), 223–230.

  • Maunder, E., Plews, D. J., & Kilding, A. E. (2018). Contextualising maximal fat oxidation during exercise: Determinants and normative values. Frontiers in Physiology, 9, 599. doi: 10.3389/fphys.2018.00599

  • McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013). Mechanisms of obesity-induced inflammation and insulin resistance: Insights into the emerging role of nutritional strategies. Frontiers in Endocrinology, 4, 1–23. doi: 10.3389/fendo.2013.00052

  • McArdle, W. D., Katch, F. I., & Katch, V. L. (2006). Essentials of exercise physiology. Lippincott Williams & Wilkins.

  • Mukherjee, S. P. (2019). A guide to research methodology: An overview of research problems, tasks and methods. CRC Press.

  • Nakano, I., Hori, H., Fukushima, A., Yokota, T., Kinugawa, S., Takada, S., Yamanashi, K., Obata, Y., Kitaura, Y., Kakutani, N., Abe, T., & Anzai, T. (2019). Enhanced echo intensity of skeletal muscle is associated with exercise intolerance in patients with heart failure. Journal of Cardiac Failure, 26(8), 685–693. doi: 10.1016/j.cardfail.2019.09.001

  • Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007). Polycystic ovary syndrome. The Lancet, 370(9588), 685–697.

  • Ong, S. R., Crowston, J. G., Loprinzi, P. D., & Ramulu, P. Y. (2018). Physical activity, visual impairment, and eye disease. Eye, 32(8), 1296–1303. doi: 10.1038/s41433-018-0081-8

  • Ortega, F. B., Lavie, C. J., & Blair, S. N. (2016). Obesity and cardiovascular disease. Circulation Research, 118(11), 1752–1770.

  • Park, H. Y., Kim, Y., & Nam, S. S. (2019). Effects of exercise training at lactate threshold and detraining for 12 weeks on body composition, aerobic performance, and stress related variables in obese women. Journal of Exercise Nutrition & Biochemistry, 23(3), 22–28. doi: 10.20463/jenb.2019.0019

  • Park, S. Y., Wilkens, L. R., Maskarinec, G., Haiman, C. A., Kolonel, L. N., & Marchand, L. L. (2018). Weight change in older adults and mortality: The multiethnic cohort study. International Journal of Obesity, 42(2), 205–212. doi: 10.1038/ijo.2017.188

  • Patel, R., & Shah, G. (2018). High-fat diet exposure from pre-pubertal age induces polycystic ovary syndrome (PCOS) in rats. Reproduction, 155(2), 139–149. doi: 10.1530/rep-17-0584

  • Pattanakuhar, S., Pongchaidecha, A., Chattipakorn, N., & Chattipakorn, S. C. (2017). The effect of exercise on skeletal muscle fibre type distribution in obesity: From cellular levels to clinical application. Obesity Research & Clinical Practice, 11(5), 112–132. doi: 10.1016/j.orcp.2016.09.012

  • Sarkar, M., Bhardwaj, R., Madabhavi, I., & Khatana, J. (2015). Osteoporosis in chronic obstructive pulmonary disease. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 9, 1–17.

  • Scott, D., Harrison, C. L., Hutchison, S., De Courten, B., & Stepto, N. K. (2017). Exploring factors related to changes in body composition, insulin sensitivity and aerobic capacity in response to a 12-week exercise intervention in overweight and obese women with and without polycystic ovary syndrome. PloS One, 12(8), 1–13. doi: 10.1371/journal.pone.0182412

  • Shadish, W. R., Cook, T. D., & Campbell, D. T. (2002). Experimental and quasi-experimental designs for generalized causal inference/William R. Shedish, Thomas D. Cook, Donald T. Campbell. Houghton Mifflin.

  • Whipp, B. J., & Davis, J. A. (1984). The ventilatory stress of exercise in obesity. American Review of Respiratory Disease, 129(2P2), S90–S92. doi: 10.1164/arrd.1984.129.2p2.s90

  • WHO. (2020). Obesity. World Health Organization. https://www.who.int/topics/obesity/en/

  • Wilmore, J. H. (1996). Increasing physical activity: Alterations in body mass and composition. The American Journal of Clinical Nutrition, 63(3), 456S–460S. doi: 10.1093/ajcn/63.3.456

  • Wing, R. R. (2004). Behavioral approaches to the treatment of obesity. In Bray, G. A & Bouchard, C. (Ed.), Handbook of obesity: Clinical applications, 2 (pp.147–167). Marcel Dekker Inc.

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JSSH(S)-1493-2021

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