PERTANIKA JOURNAL OF SCIENCE AND TECHNOLOGY

Antimicrobial peptides (AMPs), sourced from various organisms, including aquatic life, are promising alternatives to combat antibiotic resistance. Their investigation is essential amid global antibiotic resistance concerns. The invaluable impact of antibiotics on human health, having saved numerous lives, is currently at risk. The growing global incidence of antibiotic-resistant bacteria poses a serious challenge to their ability to effectively treat various illnesses. This situation demands immediate attention and the exploration of alternative medical solutions. One of the most promising alternatives to antibiotics is antimicrobial peptides (AMPs), which can treat bacterial infections, particularly those brought by multi-drug-resistant pathogens. With a particular focus on their antimicrobial properties, this systematic review aims to evaluate and classify recent AMPs isolated from aquatic organisms. This review advances knowledge of these aquatic life-derived AMPs’ potential as alternatives to conventional antibiotics by examining their unique antibacterial characteristics and modes of action. A systematic review of articles published in English between 2014 and 2024 was carried out in the Science Direct, PubMed NCBI and Google Scholar databases using keywords and inclusion and exclusion criteria. A total of 33 potential AMPs isolated from aquatic organisms had been reported, and 21 of the AMPs were reported to have functional antimicrobial activities. Continuous research and study of natural substances, particularly AMPs, remain critical in pursuing alternatives to conventional antibiotics for effective treatments in combating antibiotic resistance. Therefore, ongoing research holds significant importance in identifying and harnessing the potential of AMPs for future medical applications.

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