A high grade-point average (GPA) is considered important because of its ramifications for young people's job and career prospects. Although various studies have examined GPA in terms of its predictors, the predominant research focus has been on US samples of university students. This study determines the independent associations of socio-demographic characteristics, lifestyle activities, and academic motivation with a high GPA among a sample of 3011 Filipino university students. Data were analyzed using logistic regression, with GPA as the dependent variable and socio-demographic characteristics (sex, age, course, and weekly allowance); lifestyle activities (smoking, alcohol intake, number of social networking accounts, number of hours spent in social media, level of physical activity, and level of religious activities); and academic motivation as the independent variables. Of the 11 predictors examined, six had a statistically significant relationship with a high GPA: three socio-demographic characteristics (sex, course, and weekly allowance); two lifestyle activities (smoking and religious activities); and academic motivation. Although the regression model fitted the data well, it only explained 10.6 15.4% of the variance in the dependent variable. Prospective studies need to further validate this model, broaden the measures of the assessed predictors, and identify the statistical significance of other predictors.