Organizational citizenship behavior (OCB) has become an increasingly important aspect in improving organizational performance, employees’ work attitude and behavior. However, research that focuses on work values, work attitude and OCB is still limited specifically in higher education institution (HEI) setting. Higher education workers particularly academicians at present portray a high individualistic culture with lesser OCB due to a great pressure and demand existed in the setting. This paper aims to investigate how certain work values promote academicians’ organizational citizenship behavior and highlights the role of job satisfaction as a mediator between the aforementioned relationships. Work values in this study were looked at two aspects of terminal and instrumental. Meanwhile, OCB was looked at into two aspects namely OCB towards individual (OCBI) and organization (OCBO). This study population involved 460 academics retrieved from both private and public HEIs which were used a structural modelling approach in testing the hypotheses. The findings revealed that work values significantly predicted OCB. Both terminal and instrumental work values have a significant influence on academics’ degree of OCB. Job satisfaction on the other hand mediates the relationship between terminal work values and OCB. The implication of this paper related to theoretical, empirical and policy advancement in relation to OCB at work was included.