This preliminary research is aimed at evaluating the effectiveness of pictogram-based patient information leaflet leaflets among kindergarten students from the rural and the urban areas. Three pre-schools were selected for each area, whereby the target respondents evaluated the suitability of pictograms. The interview was conducted face-to-face and survey data was assessed using Likert scale (1=agree, 2=not sure, and 3=disagree). Chi- Square test was used to analyse data and the significant difference was set at p < 0.05. Three out of 10 questions showed significant differences while six questions presented with no significant differences (p>0.05). It is suggested that the level of understanding between the rural and the urban kindergarten students are quite discriminant towards the pictogram. At the age of six, the major difficulty faced by the students was reading. Findings showed that pictogram pictogram-based patient information leaflets aided the students' understanding of medical instruction.