The production of carbon dioxide from Karas woods under argon atmosphere was investigated using a direct pyrolysis-combustion approach. Direct burning was used in this study, using argon for pyrolysis and oxygen during combustion to look at the yield of carbon dioxide, produced at different parameters, such as the temperature, retention time and flow rate of argon, as the carrier gas. In this study, a new methodology, 2³ response surface central composite design was successfully employed for the experimental design and analysis of results. Central composite experimental design and response surface method were utilized to determine the best operating condition for a maximum carbon dioxide production. Appropriate predictable empirical linear model was developed by incorporating interaction effects of all the variables involved. The results of the analysis revealed that linear equation models fitted well with the experimental for carbon dioxide yield. Nevertheless, the R-Squared obtained using the direct pyrolysis-combustion was 0.7118, indicating that the regression line was not at the best-fitted line.