Tan Seok Shin, Zeenathul Nazariah Allaudin and Mohd. Azmi Mohd. Lila
Pertanika Journal of Tropical Agricultural Science, Volume 19, Issue 1, January 2011
Keywords: Adenovirus vector, clinical, gene therapy, human cancer, animal cancer
Published on:
Adenovirus vector is the most common used vector in clinical gene therapy. The development of adenovirus from the first generation until the helper-dependent adenovirus vector has greatly reduced toxicity and immunogenicity. The helper-dependent adenovirus can also prolong transgene expression. Tissue- or disease-specific approach has been used to improve the specificity of adenoviral vector for cancer gene therapy. This review summarizes some adenoviral gene therapy and targeting approaches available for human cancer as well as animal cancer.
ISSN 1511-3701
e-ISSN 2231-8542