Pedestrian level in the urban area is an important area where most of pedestrians' activities occur at this level. Therefore, the purpose of this study is to investigate effects of various building layouts on mean wind speed ratio at the pedestrian level. The mean wind speed ratio at the pedestrian level was analysed in order to determine whether the building layouts configured within this research are able to enhance outdoor ventilation and ensure good pedestrian comfort level. The simulation model consists of two main areas which are the upstream area and downstream area with a setback distance, d. The building layouts at upstream area are arranged in staggered arrangements (ST) or square arrangements (SQ), while the downstream areas are in a fixed staggered arrangement (ST). Packing density in both areas is 25% with three setback distances which are 3H, 5H and 7H. Based on the results, the mean wind speed ratio at the pedestrian level in a downstream area with longer setback distance will provide a higher mean speed ratio, and the influence of upstream building arrangements on the mean wind speed ratio of the downstream area decreases as the setback distance increases. Hence, the mean wind speed ratio of downstream area depends on the setback distance between the upstream and downstream areas.