8-haloalky purines were synthesized and infrared analysis (IR) carried out on them. The syntheses as well as the IR analyses are reported. The purines synthesized and studied include (i) 2,6-diamino-8-Chloromethyl purines, (ii) 2,6-diamino-8-chlorethyl purine, iii) 2,6-diamino-8-chloropropyl purine, (iv) 2-amino-6-hydroxyl-8-chloroethyl purine, (v) 2-amino-6-hydroxyl 8-(3-chlmopropyl) purine. The ultra violet UV Imax absorption of these purines were taken at PHH and results are presented. The melting points and their elemental analyses are also presented. The IR (infrared in KBr) spectra of C-8 substituted 2, 6-diamino; 5 or 2-amino -6hydroxy purines, 6 arecompared to the IR spectra of pteridines 7; 8; benzimidazole, 9; Pyrroles, 10; indole, 11 (Tables I, II, III and figures 1, 2, 3, 5 and 6). Figure 4 is presented to relate these novel purines to (i) natural liver L. casei factor (A) (ii) synthetic liver L. cacei factor (Racemic pteroylgutamic acid (C) (v) Synthetic racemic liver L. casei factor, racemic pteroylglutamic acid (D) (iv) Natural racemic liver L. casei factor pteroic acid (E).