Three experiments using a total of 191 pigs, were conducted to determine the effects of iron, bothoral supplementation and intramuscular injection in young pigs as influenced by dietary vitamin E and Selenium (Se). Piglets from sows on low vitamin E-Se gestation and lactation diets did not show any reduced tolerance to the standard dose of 100 mg iron from iron dextran when given at three days of age. Iron toxicosis was not produced when young pigs weaned at five weeks from sows on a low vitamin E-Se diet were given a second iron dextran injection of 100 mg iron. Pigs fed a low vitamin E-Se diet up to market weight did not exhibit any conclusive evidence of iron toxicity when their feed contained up to 850 ppm iron. When nine week old pigs were given an intramuscular injection of 1000 mg iron from iron dextran, there was a highly significant increase in serum iron levels; pigs on the vitamin E supplemented diets had significantly higher serum iron levels than those on the low vitamin E diet. However, the high serum-iron levels did not produce any noticeable ill effect on the animals.