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In SilicoDesigning of a Multi-Epitope Based Vaccine Candidate Against Human Adenovirus Type B3 Respiratory Infections by Utilising Various Immunoinformatics Approaches

Somnath Panda, Urmila Banik and Arun Kumar Adhikary

Pertanika Journal of Science & Technology, Volume 29, Issue 1, January 2021

DOI: https://doi.org/10.47836/pjst.29.1.32

Published: 22 January 2021

Human adenovirus type B3 (HAdV-B3) causes severe respiratory infections, hence an efficient vaccine is required. Unfortunately, the presence of numerous hexon variations makes conventional vaccine designing difficult which warrants an alternative method. Therefore, an in Silicomulti-epitope vaccine had been constructed against appropriate hexon variants of HAdV-B3. The allergenicity, antigenicity, structure, physicochemical properties along with molecular docking with TLR-3 and TLR-9 had also been predicted. The constructed vaccine had 23 different epitopes. It showed non-allergic but antigenic nature with 30hours of half-life in vitro and exhibited thermostable nature. We anticipate that this will considerably reduce the time and expense of biological work needed for future vaccine development.

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ISSN 0128-7702

e-ISSN 2231-8534

Article ID

JST-2198-2020

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