This study aimed to investigate the relationships between family functioning, social support, academic performance and self-esteem among young adults. A single survey was carried out to gather data from the subjects. The sample consisted of 378 students, aged between 18 to 26 years old. The samples were drawn through a convenience and stratified sampling from Universiti Tunku Abdul Rahman and Sunway University College, Malaysia. Bivariate correlation and linear regression were used to analyse the relationships between the variables. T-test was also employed to in order to find out the differences between genders on the academic performance and self-esteem. The results revealed that there was a significant relationship between family functioning and social support on students` self-esteem. Nevertheless, no correlation was found between family functioning and social support on the students` academic performance. On the other hand, females outperformed their male counterparts in their academic performance, but showed no significant differences in their self-esteem.