e-ISSN 2231-8542
ISSN 1511-3701
Nik Idris Yusoff, Siti Zaiton Mat So'ad, Ujang Suki, A.Z. Ibrahim, A. Latiff and Ikram M. Said
Pertanika Journal of Tropical Agricultural Science, Volume 24, Issue 1, April 2001
Keywords: Thottea corymbosa, Aristolochiaceae, Ariskanin-A, aristolochic acid, herbal medicine.
Published on:
During a phytochemical screening of higher plants at Ayer Hitam Forest Reserve, Puchong, Selangor, we collected a large amount of sample of Thottea corymbosa roots for further investigation of its bioactive constituents. The plant is a shrub commonly used in herbal medicine and could easily be found along the open forest trails. The roots of the collected sample were consecutively extracted with petroleum-ether, chloroform and methanol followed by separation of the chloroform fraction by column chromatography and preparative thin-layer chromatography. In this study we reported the isolation of an aristolactam, Ariskanin-A with a toxicity value of LC50 <200 ppm in Brine-Shrimp lethality Bioassay based on spectroscopic data and comparison with literature.
ISSN 1511-3701
e-ISSN 2231-8542