e-ISSN 2231-8542
ISSN 1511-3701
Yong Lin Chan, Nurul Aini Jamalullail, Chin Ping Tan, Prof. Dr. Mohd Yazid Abdul Manap, Teck Kim Tang, Yee Ying Lee, Eng Tong Phuah and Oi Ming Lai
Pertanika Journal of Tropical Agricultural Science, Volume 47, Issue 3, August 2024
DOI: https://doi.org/10.47836/pjtas.47.3.21
Keywords: Chewable yogurt tablet, corncob fiber, physicochemical properties, shelf-life study, simulated gastrointestinal fluid analysis
Published on: 27 August 2024
This study formulates and evaluates a novel functional food, corncob fiber-infused chewable yogurt tablets, to enhance nutritional value. The tablets have the potential to alleviate gastrointestinal symptoms in the elderly and combat malnutrition in selective eaters, potentially replacing multiple supplement tablets. Four batches of tablets underwent rigorous evaluation, considering physicochemical properties, shelf life, and probiotic viability in simulated gastrointestinal conditions. All tablets exhibited robust stability against simulated fluids (85–90% survival rate) and met desired physicochemical benchmarks. Notably, F1 had the lowest hardness (9.50 kp/cm²), while tensile strength showed no significant variance (0.93–1.18 N/mm²) between tablets. However, F3 and F4 displayed significantly longer disintegration times (41.11–52.82 min). After three months, the average bacterial viability was 7 log no. CFU/g, highlighting the tablets’ potential to deliver intact probiotics for immediate beneficial effects upon consumption. Thus, these chewable yogurt tablets offer a promising means to deliver probiotics effectively while addressing specific dietary challenges.
Amarakoon, S., & Navaratne, S. (2017). Effect of silica gel desiccant on the sensory quality of rice crackers. International Journal of Food Sciences and Nutrition, 2(6), 45–48.
American Type Culture Collection. (n.d.a). Lactobacillus delbrueckii subsp. bulgaricus (Orla-Jensen) Weiss et al. - 11842™. ATCC®. https://www.atcc.org/products/11842
American Type Culture Collection. (n.d.b). Streptococcus thermophilus Orla-Jensen - 19258™. ATCC®. https://www.atcc.org/products/19258#detailed-product-information
Augsburger, L. L., & Hoag, S. W (Eds.). (2016). Pharmaceutical dosage forms - Tablets (3rd ed.). CRC Press. https://doi.org/10.1201/b15115
Baglio, E. (2014). Chemistry and technology of yogurt fermentation. Springer. https://doi.org/10.1007/978-3-319-07377-4
Barret, R. (2018). The European Pharmacopoeia. In Medical chemistry: Fundamentals (pp. 135–144). ISTE Press. https://doi.org/10.1016/b978-1-78548-288-5.50009-3
Begley, M., Gahan, C. G. M., & Hill, C. (2005). The interaction between bacteria and bile. FEMS Microbiology Reviews, 29(4), 625–651. https://doi.org/10.1016/j.femsre.2004.09.003
Bertolino, M., Belviso, S., Bello, B. D., Ghirardello, D., Giordano, M., Rolle, L. G. C., Gerbi, V., & Zeppa, G. (2015). Influence of the addition of different hazelnut skins on the physicochemical, antioxidant, polyphenol, and sensory properties of yogurt. LWT – Food Science and Technology, 63(2), 1145–1154. https://doi.org/10.1016/j.lwt.2015.03.113
Cajigas, S. (1990). Instant yogurt composition and process. Google Patents. https://patents.google.com/patent/US4956185A
Callahan, J. C., Cleary, G. W., Elefant, M., Kaplan, G., Kensler, T., & Nash, R. A. (1982). Equilibrium moisture content of pharmaceutical excipients. Drug Development and Industrial Pharmacy, 8(3), 355–369. https://doi.org/10.3109/03639048209022105
Chaikham, P. (2015). Stability of probiotics encapsulated with Thai herbal extracts in fruit juices and yoghurt during refrigerated storage. Food Bioscience, 12, 61–66. https://doi.org/10.1016/j.fbio.2015.07.006
Chan, E. S., & Zhang, Z. (2002). Encapsulation of probiotic bacteria Lactobacillus acidophilus by direct compression. Food and Bioproducts Processing, 80(2), 78–82. https://doi.org/10.1205/09603080252938708
Chan, Y. L., Jamalullail, N. A., Tan, C. P., Abdul Manap, M. Y., & Lai, O. M. (2019). Development of bio-yoghurt chewable tablet: A review. Nutrition and Food Science, 50(3), 539–553. https://doi.org/10.1108/nfs-07-2019-0202
Dabija, A., Codină, G. G., Gâtlan, A.-M., & Rusu, L. (2018). Quality assessment of yogurt enriched with different types of fibers. CyTA - Journal of Food, 16(1), 859–867. https://doi.org/10.1080/19476337.2018.1483970
Daud, N. M., Fadzil, N. I., Yan, L. K., Makbul, I. A. A., Yahya, N. F. S., Teh, A. H., & Rahman, H. A. (2018). Knowledge, attitude, and practice regarding dietary fibre intake among Malaysian rural and urban adolescents. Malaysian Journal of Nutrition, 24(1), 77–88.
e Silva, J. P. S., Sousa, S. C., Costa, P., Cerdeira, E., Amaral, M. H., Lobo, J. S., Gomes, A. M., Pintado, M. M., Rodrigues, D., Rocha-Santos, T., & Freitas, A. C. (2013). Development of probiotic tablets using microparticles: Viability studies and stability studies. AAPS PharmSciTech, 14, 121–127. https://doi.org/10.1208/s12249-012-9898-9
EFSA Panel on Dietetic Products, Nutrition and Allergies. (2010). Scientific opinion on the substantiation of health claims related to live yoghurt cultures and improved lactose digestion (ID 1143, 2976) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 8(10), 1763. https://doi.org/10.2903/j.efsa.2010.1763
Faccia, M. (2020). Chemical and technological characterization of dairy products. Foods, 9(10), 1475. https://doi.org/10.3390/foods9101475
Floyd, C., Rooney, L. W., & Bockholt, A. J. (1995). Measuring desirable and undesirable color in white and yellow food corn. Cereal Chemistry, 72(5), 488–490.
Gilliland, S. E. (1990). Health and nutritional benefits from lactic acid bacteria. FEMS Microbiology Letters, 87(1–2), 175–188. https://doi.org/10.1016/0378-1097(90)90705-u
Goh, L.-H., Said, R. M., & Goh, K.-L. (2018). Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia. JGH Open, 2(6), 307–310. https://doi.org/10.1002/jgh3.12089
Govender, M., Choonara, Y. E., Kumar, P., du Toit, L. C., van Vuuren, S., & Pillay, V. (2014). A review of the advancements in probiotic delivery: Conventional vs. non-conventional formulations for intestinal flora supplementation. AAPS PharmSciTech, 15, 29–43. https://doi.org/10.1208/s12249-013-0027-1
Granato, D., Barba, F. J., Kovačević, D. B., Lorenzo, J. M., Cruz, A. G., & Putnik, P. (2020). Functional foods: Product development, technological trends, efficacy testing, and safety. Annual Review of Food Science and Technology, 11, 93–118. https://doi.org/10.1146/annurev-food-032519-051708
Granato, D., de Araújo Calado, V. M., & Jarvis, B. (2014). Observations on the use of statistical methods in Food Science and Technology. Food Research International, 55, 137–149. https://doi.org/10.1016/j.foodres.2013.10.024
Guarino, A., Quigley, E. M. M., & Walker, W. A. (Eds.) (2013). Probiotic bacteria and their effect on human health and well-being. Karger Medical and Scientific Publishers.
Hersh, J. (2021). Yoghurt: A global history. Reaktion Books.
Hoppert, K., Zahn, S., Jänecke, L., Mai, R., Hoffmann, S., & Rohm, H. (2013). Consumer acceptance of regular and reduced-sugar yogurt enriched with different types of dietary fiber. International Dairy Journal, 28(1), 1–7. https://doi.org/10.1016/j.idairyj.2012.08.005
Igathinathane, C., Womac, A. R., Sokhansanj, S., & Pordesimo, L. O. (2005). Sorption equilibrium moisture characteristics of selected corn stover components. Transactions of the ASAE, 48(4), 1449–1460. https://doi.org/10.13031/2013.19170
Jones, R. J., Rajabi‐Siahboomi, A. R., Levina, M., Perrie, Y., & Mohammed, A. R. (2011). The influence of formulation and manufacturing process parameters on the characteristics of lyophilized orally disintegrating tablets. Pharmaceutics, 3(3), 440–457. https://doi.org/10.3390/pharmaceutics3030440
Khokra, S. L., Parashar, B., Dhamija, H. K., Purohit, R., & Chandel, A. (2012). Formulation development and evaluation of chewable tablet of albendazole by different techniques. International Journal of Pharmacy and Pharmaceutical Science, 4(1), 461–464.
Klayraung, S., Viernstein, H., & Okonogi, S. (2009). Development of tablets containing probiotics: Effects of formulation and processing parameters on bacterial viability. International Journal of Pharmaceutics, 370(1–2), 54–60. https://doi.org/10.1016/j.ijpharm.2008.11.004
Kumar, P., & Mishra, H. N. (2004). Mango soy fortified set yoghurt: Effect of stabilizer addition on physicochemical, sensory and textural properties. Food Chemistry, 87(4), 501–507. https://doi.org/10.1016/j.foodchem.2003.12.022
Latimer, G. W. (2023). Official methods of analysis of AOAC INTERNATIONAL (22nd ed.). Oxford University Press. https://doi.org/10.1093/9780197610145.001.0001
Lee, C. M., Chan, Y. L., Gan, Y. L., Tang, T. K., Tan, C. P., & Lai, O. M. (2018). Physicochemical and sensory analysis of instant cereal beverage incorporated with corncob powder. Food Research, 2(5), 453–459. https://doi.org/10.26656/fr.2017.2(5).203
Lee, C. M., Gan, Y. Y., Chan, Y. L., Yap, K. L., Tang, T. K., Tan, C. P., & Lai, O. M. (2019). Physicochemical and sensory analyses of high fibre bread incorporated with corncob powder. International Food Research Journal, 26(5), 1609–1616.
Li, A., Zheng, J., Han, X., Yang, S., Cheng, S., Zhao, J., Zhou, W., & Lu, Y. (2023). Advances in low-lactose/lactose-free dairy products and their production. Foods, 12(13), 2553. https://doi.org/10.3390/foods12132553
Malaysian-German Chamber of Commerce and Industry., & Brandt, T. (2015). Malaysia as the Gateway to ASEAN. In Potential and challenges of dairy products in the Malaysian market 2015: Market analysis with focus on import regulations and halal certification in Malaysia (pp. 8-12). EU-Malaysia Chamber of Commerce and Industry.
Maldonado-Valderrama, J., Wilde, P., Macierzanka, A., & Mackie, A. (2011). The role of bile salts in digestion. Advances in Colloid and Interface Science, 165(1), 36–46. https://doi.org/10.1016/j.cis.2010.12.002
Mckinley, M. C. (2005). The nutrition and health benefits of yoghurt. International Journal of Dairy Technology, 58(1), 1-12. https://doi.org/10.1111/j.1471-0307.2005.00180.x
Millette, M., Nguyen, A., Amine, K. M., & Lacroix, M. (2013). Gastrointestinal survival of bacteria in commercial probiotic products. International Journal of Probiotics and Prebiotics, 8(4), 149–156.
Mordor Intelligence. (n.d.). Asia-Pacific yogurt market size and share analysis – Growth trends and forecast up to 2029. https://www.mordorintelligence.com/industry-reports/asia-pacific-yogurt-market
Nagashima, A. I., Pansiera, P. E., Baracar, M. M., & Gómez, R. J. H. C. (2013). Development of effervescent products, in powder and tablet form, supplemented with probiotics Lactobacillus acidophilus and Saccharomyces boulardii. Food Science and Technology, 33(4), 605–611. https://doi.org/10.1590/s0101-20612013000400002
Peng, G., Chen, X., Wu, W., & Jiang, X. (2007). Modeling of water sorption isotherm for corn starch. Journal of Food Engineering, 80(2), 562–567. https://doi.org/10.1016/j.jfoodeng.2006.04.063
Ramirez-Santiago, C., Ramos-Solis, L., Lobato-Calleros, C., Peña-Valdivia, C., Vernon-Carter, E. J., & Alvarez-Ramírez, J. (2010). Enrichment of stirred yogurt with soluble dietary fiber from Pachyrhizus erosus L. Urban: Effect on syneresis, microstructure and rheological properties. Journal of Food Engineering, 101(3), 229–235. https://doi.org/10.1016/j.jfoodeng.2010.06.023
Rana, A., Khokra, S. L., Chandel, A., Nanda, G. P., & Sahu, R. K. (2011). Overview on roll compaction/dry granulation process. Pharmacologyonline, 3, 286–298.
Renu., Dahiya, J., Jalwal, P., & Singh, B. (2015). Chewable tablets: A comprehensive review. The Pharma Innovation Journal, 4(5), 100–105.
Reynolds, A., Mann, J., Cummings, J., Winter, N., Mete, E., & Te Morenga, L. (2019). Carbohydrate quality and human health: A series of systematic reviews and meta-analyses. The Lancet, 393(10170), 434–445. https://doi.org/10.1016/s0140-6736(18)31809-9
Robinson, R. K. (1992). Therapeutic properties of fermented milks. International Journal of Dairy Technology, 45(3), 90. https://doi.org/10.1111/j.1471-0307.1992.tb01789.x
Robinson, R. L., Damon, J. R., Mossop, J. R., & Palmer, M. D. (2001). Soft, convex shaped chewable tablets having reduced friability. https://www.lens.org/lens/patent/129-420-848-493-113
Sadler, G. D., & Murphy, P. A. (2010). pH and titratable acidity. In Food analysis (pp. 219–238). Springer. https://doi.org/10.1007/978-1-4419-1478-1_13
Sah, B. N. P., Vasiljevic, T., McKechnie, S., & Donkor, O. N. (2016). Physicochemical, textural, and rheological properties of probiotic yogurt fortified with fibre-rich pineapple peel powder during refrigerated storage. LWT, 65, 978–986. https://doi.org/10.1016/j.lwt.2015.09.027
Saha, U. S., Misra, R., Tiwari, D., & Prasad, K. N. (2016). A cost-effective anaerobic culture method and its comparison with a standard method. The Indian Journal of Medical Research, 144(4), 611–613. https://doi.org/10.4103/0971-5916.200881
Saint-Eve, A., Lévy, C., Le Moigne, M., Ducruet, V., & Souchon, I. (2008). Quality changes in yogurt during storage in different packaging materials. Food Chemistry, 110(2), 285–293. https://doi.org/10.1016/j.foodchem.2008.01.070
Shah, N. P. (2007). Functional cultures and health benefits. International Dairy Journal, 17(11), 1262–1277. https://doi.org/10.1016/j.idairyj.2007.01.014
Tomic, N., Dojnov, B., Miocinovic, J., Tomasevic, I., Smigic, N., Djekic, I., & Vujcic, Z. (2017). Enrichment of yogurt with insoluble dietary fiber from triticale – A sensory perspective. LWT, 80, 59–66. https://doi.org/10.1016/j.lwt.2017.02.008
United States Pharmacopeia. (2012). Weight variation of dietary supplements. USP. https://doi.org/10.31003/USPNF_M99985_02_01
United States Pharmacopeial Convention. (2015). Dietary Supplements Compendium. USP. https://www.usp.org/sites/default/files/usp/document/products-services/products/2015-dsc-vol-1-table-of-contents-ref-standard-index.pdf
Xie, P., Luo, M., Deng, X., Fan, J., & Xiong, L. (2023). Outcome-specific efficacy of different probiotic strains and mixtures in irritable bowel syndrome: A systematic review and network meta-analysis. Nutrients, 15(17), 3856. https://doi.org/10.3390/nu15173856
Zayed, G., & Roos, Y. H. (2004). Influence of trehalose and moisture content on survival of Lactobacillus salivarius subjected to freeze-drying and storage. Process Biochemistry, 39(9), 1081–1086. https://doi.org/10.1016/s0032-9592(03)00222-x
Zhang, J., & Mittal, G. S. (2013). Prediction of equilibrium moisture content of various foods using a neural network. International Journal of Food Properties, 16(6), 1211–1221. https://doi.org/10.1080/10942912.2011.582974
ISSN 1511-3701
e-ISSN 2231-8542