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A Simple and Clean Method for Methoxymethylation of Phenols

Faujan B, H. Ahmad and J. Malcolm Bruce

Pertanika Journal of Tropical Agricultural Science, Volume 12, Issue 1, April 1989

Keywords: Methoxymethyl ethers of phenols.

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A simple and clean procedure for the preparation of methoxymethyl ethers (MOM = CH2 OMe) of phenols having internally hydrogen bonded hydroxy groups is described. Thus treatment of 2,5-dihydroxybenzaldehyde (1) with a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperature gives 2.5-bis- (methoxymethoxy)benzaldehyde (2) in 57% yield; under similar conditions, the methoxymethyl ether (6) of salicylaldehyde was isolated in 75% yield. Yields of 61-81 %, not optimised, of methoxymethyl ethers of several phenols lacking internal hydrogen bonding were also obtained.

ISSN 1511-3701

e-ISSN 2231-8542

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