This study examined self-esteem ofdrugusers and non-users before any of the subjects engaged in initial drug use. Subjects were 183 drugusers receiving treatment atfive Government Rehabilitation Centers, and 200 non-drugusers drawn from a universitiy. Development of initial drug use was found to be related to self-esteem of the subjects. The result may have certain implications both in relation to the etiology of drug use and to its treatment. by comparing peak height of sample to those of standards. The method demonstrated excellent reproducibility and recoveries of the added acid